Country: World Source: Pan American Health Organization Please refer to the attached file. Globally, between January 2022 and as of 31 March 2026, a total of 181, 164 confirmed mpox cases, including 492 deaths, were reported in 144 Member States across the six regions of the World Health Organization (WHO). In 2025, 53, 562 cases were confirmed, including 219 deaths. In 2026, as of 28 February 2026, 2, 794 confirmed cases of mpox had been recorded, including eight deaths. Over the past 12 months, a gradual decrease in the monthly number of reported mpox cases was observed, primarily due to a decline in reported cases in the African and Americas regions. Mpox continues to spread globally, driven by the circulation of various virus clades (Ia, Ib, IIa, and IIb), each with distinct epidemiological characteristics. Clade IIb has been primarily responsible for global expansion since 2022.
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