World: Multi-country outbreak of mpox, External situation report #65 – 30 April 2026

Country: World Source: World Health Organization Please refer to the attached file. Highlights • Transmission of mpox continues mostly within sexual networks, affecting men and women, often followed by household transmission and, in some areas, affecting all age groups. All clades of monkeypox virus (MPXV) continue to circulate. Rapid containment of mpox outbreaks is essential to prevent community transmission in any setting. • In March 2026, 48 countries across all WHO regions reported a total of 1235 confirmed mpox cases, including five deaths (case fatality ratio [CFR] 0. 4%). Of these cases, 70. 4% were reported in the WHO African Region. • Four WHO regions – the Region of the Americas, African, European, and South-East Asian regions – reported a decline in confirmed cases in March, compared to February 2026, while the Eastern Mediterranean and Western Pacific Region reported an increase in confirmed cases. • Sixteen countries in Africa reported active transmission of mpox in the last six weeks (9 March – 19 April 2026), with 969 confirmed cases, including three deaths (CFR 0. 3%). Madagascar, the Democratic Republic of the Congo, Guinea, Kenya, and Burundi reported the highest number of cases during this period. • Four countries, Colombia, Denmark, Ecuador and Singapore, reported mpox due to clade Ib MPXV for the first time. Poland and Slovakia reported mpox due to clade I MPXV for the first time, pending subclade identification. • Outside Africa, Argentina, Denmark, Germany, Pakistan, Portugal, Singapore, Spain, and the United Kingdom of Great Britain and Northern Ireland reported community transmission of clade Ib MPXV, including among men who have sex with men. • Pakistan has reported a healthcare-associated mpox outbreak in Sindh province, involving neonates, infants, and adults. In the past month, the province has reported 29 confirmed cases, including eight deaths (case fatality ratio: 28%), and one additional death in a suspected case. About half of cases, and all deaths were reported among infants younger than six months of age. • Qatar has reported a travel-related case of mpox with a clade Ib/IIb recombinant MPXV strain, the third such reported case globally, following previous case reports in India and the United Kingdom of Great Britain and Northern Ireland. The patient has recovered and no secondary cases have been reported to date.

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